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Article

Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression.

Brain : a journal of neurology - 18 Apr 2022

Li Shiwu, Li Jiao, Liu Jiewei, Wang Junyang, Li Xiaoyan, Huo Yongxia, Li Yifan, Liu Yixing, Li Ming, Xiao Xiao, Luo Xiong-Jian

Abstract excerpt

Genome-wide association studies have shown that genetic variants at 2q33.1 are strongly associated with schizophrenia. However, potential causal variants in this locus and their roles in schizophrenia remain unknown. Here, we identified two functional variants (rs796364 and rs281759) that disrupt CTCF, RAD21 and FOXP2 binding at 2q33.1. We systematically investigated the regulatory mechanisms of these two...

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Identifiers

PMID: 34581804
DOI: 10.1093/brain/awab357
PMCID: PMC9014752

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