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Article

ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2021

Arakawa Akiko, Reeves Emma, Vollmer Sigrid, Arakawa Yukiyasu, He Mengwen, Galinski Adrian, Stöhr Julia, Dornmair Klaus, James Edward, Prinz Jörg C

Abstract excerpt

Autoimmune diseases develop when autoantigens activate previously quiescent self-reactive lymphocytes. Gene-gene interaction between certain HLA class I risk alleles and variants of the endoplasmic reticulum aminopeptidase ERAP1 controls the risk for common immune-mediated diseases, including psoriasis, ankylosing spondylitis, and Behçet disease. The functional mechanisms underlying this statistical association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34580106
DOI: 10.4049/jimmunol.2100686
PMCID: PMC7611875

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ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation.PMID 34580106Read ↗

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