Article
Associations of ERAP1 coding variants and domain specific interaction with HLA-C∗06 in the early onset psoriasis patients of India.
Human immunology - 1 Nov 2017
Das Anamika, Chandra Aditi, Chakraborty Joyeeta, Chattopadhyay Abhijit, Senapati Swapan, Chatterjee Gobinda, Chatterjee Raghunath
Abstract excerpt
Interferon-γ-induced aminopeptidase ERAP1 trims peptides within the endoplasmic reticulum so that they can be loaded onto MHC class I and presented to the CD8+ T-cells. ERAP1 association and its interaction with HLA-C∗06 is controversial across different populations. We have investigated the association and possible functional role of non-synonymous SNPs at different exons of ERAP1 (rs26653: Arg127Pro, rs30187:...
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