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Article

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.

Cell host & microbe - 12 May 2021

Cerutti Gabriele, Guo Yicheng, Zhou Tongqing, Gorman Jason, Lee Myungjin, Rapp Micah, Reddem Eswar R, Yu Jian, Bahna Fabiana, Bimela Jude, Huang Yaoxing, Katsamba Phinikoula S, Liu Lihong, Nair Manoj S, Rawi Reda, Olia Adam S, Wang Pengfei, Zhang Baoshan, Chuang Gwo-Yu, Ho David D, Sheng Zizhang, Kwong Peter D, Shapiro Lawrence

Abstract excerpt

Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral spike. While RBD-directed antibodies have been extensively studied, far less is known about NTD-directed antibodies. Here, we report cryo-EM and crystal structures for seven potent NTD-directed neutralizing antibodies in complex with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33789084
DOI: 10.1016/j.chom.2021.03.005
PMCID: PMC7953435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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