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Article

The Splice of Life: Does RNA Processing Have a Role in HIV-1 Persistence?

2 Sept 2021

Abstract excerpt

Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure. However, these HIV-1 reservoirs are not transcriptionally silent, and viral transcripts can be detected in most ART-treated individuals. HIV-1 latency is regulated at the transcriptional and at...

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PMID: 34578332
DOI: 10.3390/v13091751

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