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Article

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.

Nature biotechnology - 1 Feb 2013

Liu Yun, Aryee Martin J, Padyukov Leonid, Fallin M Daniele, Hesselberg Espen, Runarsson Arni, Reinius Lovisa, Acevedo Nathalie, Taub Margaret, Ronninger Marcus, Shchetynsky Klementy, Scheynius Annika, Kere Juha, Alfredsson Lars, Klareskog Lars, Ekström Tomas J, Feinberg Andrew P

Abstract excerpt

Epigenetic mechanisms integrate genetic and environmental causes of disease, but comprehensive genome-wide analyses of epigenetic modifications have not yet demonstrated robust association with common diseases. Using Illumina HumanMethylation450 arrays on 354 anti-citrullinated protein antibody-associated rheumatoid arthritis cases and 337 controls, we identified two clusters within the major histocompatibility...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

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Share to Major Histocompatibility Complex

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 23334450
DOI: 10.1038/nbt.2487
PMCID: PMC3598632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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