Article
Biological consequences of formation and repair of complex DNA damage.
Cancer letters - 31 Dec 2012
Magnander Karin, Elmroth Kecke
Abstract excerpt
Endogenous processes or genotoxic agents can induce many types of single DNA damage (single-strand breaks, oxidized bases and abasic sites). In addition, ionizing radiation induces complex lesions such as double-strand breaks and clustered damage. To preserve the genomic stability and prevent carcinogenesis, distinct repair pathways have evolved. Despite this, complex DNA damage can cause severe problems and is...
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