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Processing of DNA damage clusters in human cells: current status of knowledge

7 Nov 2007

Abstract excerpt

Eukaryotic cells exposed to DNA damaging agents activate important defensive pathways by inducing multiple proteins involved in DNA repair, cell cycle checkpoint control and potentially apoptosis. After the acceptance of the hypothesis that oxidatively generated clustered DNA lesions (OCDL: closely spaced DNA lesions) can be induced even by low doses of ionizing radiation or even endogenously, and significant...

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PMID: 18075671
DOI: 10.1039/b713178j

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