The inositol 1,4,5-trisphosphate receptor regulates epidermal cell migration in Caenorhabditis elegans.

doi:10.1016/j.cub.2004.10.001

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Article

The inositol 1,4,5-trisphosphate receptor regulates epidermal cell migration in Caenorhabditis elegans.

Current biology : CB - 26 Oct 2004

Thomas-Virnig Christina L, Sims Paul A, Simske Jeffrey S, Hardin Jeff

Abstract excerpt

Polarized migration and spreading of epithelial sheets is important during many processes in vivo, including embryogenesis and wound healing. However, the signaling pathways that regulate epithelial migrations are poorly understood. To identify molecular components that regulate the spreading of epithelial sheets, we performed a screen for mutations that perturb epidermal cell migration during embryogenesis in...

Topics

Animals
Blotting, Western
Caenorhabditis elegans
Calcium Channels
Cell Movement
DNA Primers
Epidermal Cells
Epidermis
Gene Components
Immunohistochemistry
Inositol 1,4,5-Trisphosphate Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrocyclic Compounds

Microscopy, Confocal

Microscopy, Video

Mutation

Oxazoles

Pseudopodia

Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed

Identifiers

PMID: 15498499
DOI: 10.1016/j.cub.2004.10.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15498499-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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