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Article

A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis

19 Nov 2019

Abstract excerpt

BACKGROUND & AIMS: Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and enterocyte death. Given that necroptosis is a proinflammatory cell death process that is linked to bacterial signaling, we investigated its potential role in NEC, and the mechanisms involved. METHODS: Human and mouse NEC intestine were...

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PMID: 31756560
DOI: 10.1016/j.jcmgh.2019.11.002

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