Article
Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer.
Carcinogenesis - 26 Oct 2021
Fujisawa Ryosuke, Iwaya Takeshi, Endo Fumitaka, Idogawa Masashi, Sasaki Noriyuki, Hiraki Hayato, Tange Shoichiro, Hirano Tomomi, Koizumi Yuka, Abe Masakazu, Takahashi Tomoko, Yaegashi Mizunori, Akiyama Yuji, Masuda Mari, Sasaki Akira, Takahashi Fumiaki, Sasaki Yasushi, Tokino Takashi, Nishizuka Satoshi S
Abstract excerpt
We investigated whether early circulating tumor DNA (ctDNA) changes, measured using digital PCR (dPCR), can predict later chemotherapy responses in esophageal squamous cell cancer (ESCC). We compared the dynamics of ctDNA and tumor volumes during chemotherapy in 42 ESCC. The accuracy of predictions of later chemotherapy responses was evaluated by the ratio of the variant allele frequency of ctDNA...
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