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Predictive role of circulating tumor DNA and blood-based tumor mutational burden in esophageal squamous cell carcinoma receiving definitive chemoradiotherapy combined with toripalimab: Exploratory analyses of a phase II study (EC-CRT-001)

2023-07-11

Abstract excerpt

<title>Abstract</title> <p>The combination of toripalimab (an anti-PD-1 antibody) with definitive chemoradiotherapy (CRT) demonstrated encouraging efficacy against locally advanced esophageal squamous cell carcinoma (ESCC) in the EC-CRT-001 phase II trial. This exploratory analysis evaluated the role of circulating tumor DNA (ctDNA) and blood-based tumor mutational burden (bTMB) in predicting the response and sur...

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Literature Corpus work
3d8818f2-b801-5843-8674-19b7357eccce
DOI
10.21203/rs.3.rs-3124182/v1
Open publication

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