Article
APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment.
American journal of Alzheimer's disease and other dementias - 1 Aug 2012
Sun Xiaoyan, Nicholas Joyce, Walker Aljoeson, Wagner Mark T, Bachman David
Abstract excerpt
BACKGROUND: Although an association between the apolipoprotein E (APOE) ε4 allele and increased risk of Alzheimer's disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. METHODS: Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a retrospective review. RESULTS: Comparison of age, age at onset, education,...
Topics
- Age of Onset
- Aged
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Cognition Disorders
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Sensitivity and Specificity