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Article

The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm.

Gene - 30 Dec 2018

Xu Jichong, Yan Shuo, Tan Huaqiao, Ma Lin, Feng Hao, Han Hongjie, Pan Minmin, Yu Limin, Fang Chun

Abstract excerpt

Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs), but the molecular mechanisms of these alterations are unclear. The aim of this study was therefore to identify the molecular mechanism of VSMC-mediated IAs at clinical and cellular levels. We used bioinformatic and biochemical analyses to show that the microRNA (miR)-143/145 cluster was involved in...

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PMID: 30201338
DOI: 10.1016/j.gene.2018.09.010

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