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Article

Association analysis of miRNA-related genetic polymorphisms in miR-143/145 and KRAS with colorectal cancer susceptibility and survival.

Bioscience reports - 30 Apr 2021

Wang Danyang, Liu Qingmin, Ren Yanjun, Zhang Yan, Wang Xin, Liu Bing

Abstract excerpt

BACKGROUND: There is accumulating evidence of aberrant expression of miR-143 and miR-145 and their target gene KRAS in colorectal cancer (CRC). We hypothesize that single nucleotide polymorphisms (SNPs) within or near mRNA-microRNA (miRNA) binding sites may affect miRNA/target gene interaction, resulting in differential mRNA/protein expression and promoting the development and progression of CRC. METHODS: We...

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Identifiers

PMID: 33825830
DOI: 10.1042/BSR20204136
PMCID: PMC8062955

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