Article
Enhancing discoveries of molecular QTL studies with small sample size using summary statistic imputation.
Briefings in bioinformatics - 17 Jan 2022
Wang Tao, Liu Yongzhuang, Yin Quanwei, Geng Jiaquan, Chen Jin, Yin Xipeng, Wang Yongtian, Shang Xuequn, Tian Chunwei, Wang Yadong, Peng Jiajie
Abstract excerpt
Quantitative trait locus (QTL) analyses of multiomic molecular traits, such as gene transcription (eQTL), DNA methylation (mQTL) and histone modification (haQTL), have been widely used to infer the functional effects of genome variants. However, the QTL discovery is largely restricted by the limited study sample size, which demands higher threshold of minor allele frequency and then causes heavy missing molecular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.