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BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability

7 Oct 2021

Abstract excerpt

Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow characterized by chromosome instability (CIN), which contributes to the acquisition of heterogeneity, along with MM progression, drug resistance, and relapse. In this study, we elucidated that the expression of BUB1B increased strikingly in MM patients and was closely correlated with poor outcomes. Overexpression of BUB1B facilitated...

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PMID: 34620840
DOI: 10.1038/s41392-021-00746-6

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