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DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

30 Apr 2020

Abstract excerpt

Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer cells is still a major limitation for radiotherapy applications. Efforts are continuously ongoing to explore sensitizing targets and develop radiosensitizers for improving the outcomes of radiotherapy. DNA double-strand breaks are the most lethal lesions induced by ionizing radiation...

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PMID: 32355263
DOI: 10.1038/s41392-020-0150-x

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