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Article

Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants.

The Journal of biological chemistry - 1 Oct 2021

Upadhyay Vaibhav, Lucas Alexandra, Panja Sudipta, Miyauchi Ryuki, Mallela Krishna M G

Abstract excerpt

Emergence of new severe acute respiratory syndrome coronavirus 2 variants has raised concerns related to the effectiveness of vaccines and antibody therapeutics developed against the unmutated wildtype virus. Here, we examined the effect of the 12 most commonly occurring mutations in the receptor-binding domain of the spike protein on its expression, stability, activity, and antibody escape potential. Stability...

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Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34543625
DOI: 10.1016/j.jbc.2021.101208
PMCID: PMC8445900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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