Article

Interplay between receptor binding, immune escape and protein stability determines the natural selection of SARS-CoV-2 variants

2021-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Emergence of new SARS-CoV-2 variants has raised concerns at the effectiveness of vaccines and antibody therapeutics developed against the unmutated wild-type virus. We examined the effect of 12 most commonly occurring mutations in the receptor binding domain on its expression, stability, activity, and antibody escape potential-some of the factors that may influence the natural selection of mutan...

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Literature Corpus work: ea6cb82c-f00a-5502-be92-73b5296bebe2
DOI: 10.1101/2021.05.23.445348

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