Article
Genetic and epigenetic basis of hepatoblastoma diversity.
Nature communications - 20 Sept 2021
Nagae Genta, Yamamoto Shogo, Fujita Masashi, Fujita Takanori, Nonaka Aya, Umeda Takayoshi, Fukuda Shiro, Tatsuno Kenji, Maejima Kazuhiro, Hayashi Akimasa, Kurihara Sho, Kojima Masato, Hishiki Tomoro, Watanabe Kenichiro, Ida Kohmei, Yano Michihiro, Hiyama Yoko, Tanaka Yukichi, Inoue Takeshi, Ueda Hiroki, Nakagawa Hidewaki, Aburatani Hiroyuki, Hiyama Eiso
Abstract excerpt
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary predisposition and acquired molecular aberrations related to HB clinicopathological diversity are not well understood. Here, we perform an integrative genomic profiling of 163 pediatric liver tumors (154 HBs and nine hepatocellular carcinomas) based on the data acquired from a cohort study (JPLT-2). The total number of somatic...
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