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IHC versus FISH versus NGS to detect ALK gene rearrangement in NSCLC: all questions answered?

22 Mar 2021

Abstract excerpt

Aims Anaplastic lymphoma kinase ( ALK ) rearranged non-small cell lung carcinoma (NSCLC) is a distinct molecular subtype and rapid approval of ALK tyrosine kinase inhibitors (TKIs) has necessitated rapid and sensitive diagnostic modalities for the detection of this alteration. Gene rearrangements can be identified using many techniques including fluorescence in situ hybridisation (FISH), reverse...

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PMID: 33753563
DOI: 10.1136/jclinpath-2021-207408

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