Heritable Variants in the Chromosome 1q22 Locus Increase Gastric Cancer Risk via Altered Chromatin Looping and Increased UBAP2L Expression.

doi:10.1158/1541-7786.MCR-21-0001

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Heritable Variants in the Chromosome 1q22 Locus Increase Gastric Cancer Risk via Altered Chromatin Looping and Increased UBAP2L Expression.

Molecular cancer research : MCR - 1 Dec 2021

Guan Wei, Yang Nan, Zuo Xianglin, Wang Xuchun, Cao Pingping, Chu Ying, Qin Zhongyong, Cheng He, Shi Xiao, Ma Tingzheng, Xu Zekuan, Sun Yujie

Abstract excerpt

Genome-wide association studies (GWAS) have implicated the 1q22 gastric cancer risk locus in disease, but little is known about its underlying oncogenic functions. This study represents a systematic investigation of the biological significance and potential mechanism associated with the gastric cancer risk of SNP rs2075570(C>T) in 1q22. We identified two functional germline variations (rs2049805-C and...

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PMID: 34535561
DOI: 10.1158/1541-7786.MCR-21-0001

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