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Article

Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

American journal of human genetics - 2 Jul 2026

Hu Beiping, Zhang Min, Yu Yuhui, Liu Yongchao, Wang Jiawei, Zhang Aiping, Li Qian, Gao Yun, Li Zhe, Bian Lijun, Gu Yuanliang, Zhu Xia, She Qiang, Gao Xuefeng, Deng Bin, Fang Haisheng, Hu Caihong, Chen Yuheng, Chen Yan, Wang Xinya, Yin Xianyong, Zhu Meng, Wang Lu, Jiang Yue, Chen Jiaping, Dai Juncheng, Ma Hongxia, Ding Yanbing, Yan Caiwang, Jin Guangfu

Abstract excerpt

Genome-wide association studies (GWASs) have identified at least 17 genetic variants associated with gastric cancer risk. However, the underlying genetic regulatory mechanisms remain poorly understood. We systematically performed genome-wide analyses of expression quantitative trait loci (eQTLs), splicing QTLs (sQTLs), and alternative polyadenylation QTLs (apaQTLs) using gastric biopsy tissues from 262 Chinese...

Topics

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Gene Expression Regulation, Neoplastic
Genome-Wide Association Study
Linkage Disequilibrium
Polyadenylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Stomach Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 42392035
DOI: 10.1016/j.ajhg.2026.06.002
PMCID: PMC13504352

Genes

ATXN2
DIP2B
FDPS
PSCA
RMC1
UBE2L3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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