A functional NKILA variant (rs2273534) drives genetic susceptibility and oncogenic progression in gastric cancer via the miR-4424/OAS2 pathway.

doi:10.1007/s10120-025-01681-z

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Article

A functional NKILA variant (rs2273534) drives genetic susceptibility and oncogenic progression in gastric cancer via the miR-4424/OAS2 pathway.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2026

Hu Li, Li Yuan, Zhao Xinyu, Shen Kuan, Wang Jiawei, Cao Wei, Li Pengyu, Zhai Shengyong, Zhang Diancai, Yang Li

Abstract excerpt

OBJECTIVE: This research examines how NF-κB Interacting LncRNA (NKILA) and its functional variant rs2273534 influence gastric cancer (GC) risk, development, and prognosis, along with the molecular pathways involved. METHODS: 840 GC patients and 840 healthy controls participated in a case-control research. Genetic association analyses, molecular experiments (qRT-PCR, Western blot, functional assays), and...

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PMID: 41186887
DOI: 10.1007/s10120-025-01681-z

Genes

GC
OAS2

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