Article
High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2021
Bernhardt Anja, Häberer Saskia, Xu JingJing, Damerau Hannah, Steffen Johannes, Reichardt Charlotte, Wolters Katharina, Steffen Hannes, Isermann Berend, Borucki Katrin, Artelt Nadine, Endlich Nicole, Kozyraki Renata, Brandt Sabine, Lindquist Jonathan A, Mertens Peter R
Abstract excerpt
High salt diet (HSD) is a hallmark of blood pressure elevations, weight gain and diabetes onset in the metabolic syndrome. In kidney, compensatory mechanisms are activated to balance salt turnover and maintain homeostasis. Data on the long-term effects of HSD with respect to tubular cell functions and kidney architecture that exclude confounding indirect blood pressure effects are scarce. Additionally we focus on...
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