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Article

Aging and chronic high-fat feeding negatively affect kidney size, function, and gene expression in CTRP1-deficient mice.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jan 2021

Rodriguez Susana, Little Hannah C, Daneshpajouhnejad Parnaz, Fenaroli Paride, Tan Stefanie Y, Sarver Dylan C, Delannoy Michael, Talbot C Conover, Jandu Sandeep, Berkowitz Dan E, Pluznick Jennifer L, Rosenberg Avi Z, Wong G William

Abstract excerpt

C1q/TNF-related protein 1 (CTRP1) is an endocrine factor with metabolic, cardiovascular, and renal functions. We previously showed that aged Ctrp1-knockout (KO) mice fed a control low-fat diet develop renal hypertrophy and dysfunction. Since aging and obesity adversely affect various organ systems, we hypothesized that aging, in combination with obesity induced by chronic high-fat feeding, would further...

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Identifiers

PMID: 33085906
DOI: 10.1152/ajpregu.00139.2020
PMCID: PMC7847058

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