Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2022

Morini Aurélien, Drossart Tom, Timsit Marc-Olivier, Sibony Mathilde, Vasiliu Viorel, Gimenez-Roqueplo Anne-Paule, Favier Judith, Badoual Cécile, Mejean Arnaud, Burnichon Nelly, Verkarre Virginie

Abstract excerpt

Low-grade oncocytic renal tumor (LOT) is an emerging provisional entity, described as rare solid renal oncocytic/eosinophilic tumor sharing diffuse CK7 and negative CD117 immunoprofile. The links between LOT and other eosinophilic chromophobe like-renal cell carcinomas (RCC) are currently discussed. We sequenced tumoral DNA with a next generation sequencing panel for kidney cancer and carried out...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma, Oxyphilic
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to Forkhead Transcription Factors

Share to Kidney Neoplasms

Share to Mutation

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 34531523
DOI: 10.1038/s41379-021-00906-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.PMID 34531523Read ↗

Low-grade oncocytic tumor of the kidney—a clinical, pathological, and next generation sequencing-based study of 20 tumorsSemantic proximity Read ↗

Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.Semantic proximity Read ↗

Low-grade oncocytic tumor of kidney harboring TSC/MTOR mutation: clinicopathologic, immunohistochemical and molecular characteristics support a distinct entity.Semantic proximity Read ↗

Low-grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity.Semantic proximity Read ↗

Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT.Semantic proximity Read ↗

Low-grade oncocytic tumour (LOT) of the kidney is characterised by GATA3 positivity, FOXI1 negativity and mTOR pathway mutations.Semantic proximity Read ↗

Features and molecular genetic study of low-grade oncocytic tumor of the kidney.Semantic proximity Read ↗

TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic BackgroundSemantic proximity Read ↗

TSC/MTOR-associated Eosinophilic Renal Tumors Exhibit a Heterogeneous Clinicopathologic SpectrumSemantic proximity Read ↗

Concordance of MTOR Pathway Mutations and the Diagnosis of Renal Low-Grade Oncocytic Tumor (LOT).Semantic proximity Read ↗

L1 Cell Adhesion Molecule (L1CAM) Expression and Molecular Alterations Distinguish Low-Grade Oncocytic Tumor From Eosinophilic Chromophobe Renal Cell Carcinoma.Semantic proximity Read ↗

Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.