Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT.

doi:10.1007/s00428-023-03673-9

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Article

Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT.

Virchows Archiv : an international journal of pathology - 1 Nov 2023

Ricci Costantino, Ambrosi Francesca, Franceschini Tania, Giunchi Francesca, Grillini Alessia, Franchini Eugenia, Grillini Marco, Schiavina Riccardo, Massari Francesco, Mollica Veronica, Tateo Valentina, Bianchi Federico Mineo, Bianchi Lorenzo, Droghetti Matteo, Maloberti Thais, Tallini Giovanni, Colecchia Maurizio, Acosta Andres Martin, Lobo João, Trpkov Kiril, Fiorentino Michelangelo, de Biase Dario

Abstract excerpt

The 2022 WHO classification of urinary and male genital tumors introduced several novel kidney entities exhibiting eosinophilic/oncocytic features with specific mutational backgrounds. Thus, molecular techniques, such as next-generation sequencing (NGS), became more commonly used for their evaluation. We studied 12 low-grade oncocytic tumors (LOT) of the kidney (from 11 patients), identified in a cohort of 210...

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PMID: 37845471
DOI: 10.1007/s00428-023-03673-9
PMCID: PMC10673759

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