Low-grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity.

doi:10.1111/his.14816

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Low-grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity.

Histopathology - 1 Jan 2023

Williamson Sean R, Hes Ondrej, Trpkov Kiril, Aggarwal Aditi, Satapathy Abhishek, Mishra Sourav, Sharma Shivani, Sangoi Ankur, Cheng Liang, Akgul Mahmut, Idrees Muhammad, Levin Albert, Sadasivan Sudha, San Miguel Fraile Pilar, Rogala Joanna, Comperat Eva, Berney Daniel M, Bulimbasic Stela, McKenney Jesse K, Jha Shilpy, Sampat Nakul Y, Mohanty Sambit K

Abstract excerpt

Low-grade oncocytic tumour (LOT) of the kidney has recently emerged as a potential novel tumour type. Despite similarity to oncocytoma or eosinophilic chromophobe renal cell carcinoma, it shows diffuse keratin 7 immunohistochemistry (IHC) and negative KIT (CD117), which differs from both. We aimed to identify the molecular characteristics of these tumours. Seventeen tumours (one male, 16 female, nine previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma, Oxyphilic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to Class I Phosphatidylinositol 3-Kinases

Share to GATA3 Transcription Factor

Share to Kidney

Share to Kidney Neoplasms

Share to Neoplasm Recurrence, Local

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 36208048
DOI: 10.1111/his.14816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity.PMID 36208048Read ↗

Low-grade oncocytic tumour (LOT) of the kidney is characterised by GATA3 positivity, FOXI1 negativity and mTOR pathway mutations.Semantic proximity Read ↗

Low-grade oncocytic tumor of the kidney—a clinical, pathological, and next generation sequencing-based study of 20 tumorsSemantic proximity Read ↗

Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.Semantic proximity Read ↗

Low-grade oncocytic tumor of kidney harboring TSC/MTOR mutation: clinicopathologic, immunohistochemical and molecular characteristics support a distinct entity.Semantic proximity Read ↗

Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT.Semantic proximity Read ↗

Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.Semantic proximity Read ↗

TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic BackgroundSemantic proximity Read ↗

Concordance of MTOR Pathway Mutations and the Diagnosis of Renal Low-Grade Oncocytic Tumor (LOT).Semantic proximity Read ↗

Features and molecular genetic study of low-grade oncocytic tumor of the kidney.Semantic proximity Read ↗

Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases.Semantic proximity Read ↗

Eosinophilic Renal Cell Tumors With a TSC and MTOR Gene Mutations Are Morphologically and Immunohistochemically Heterogenous: Clinicopathologic and Molecular Study.Semantic proximity Read ↗

TSC/MTOR-associated Eosinophilic Renal Tumors Exhibit a Heterogeneous Clinicopathologic SpectrumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.