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Article

Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.

PloS one - 11 Jun 2008

Zheng Huajun, Lu Liangdong, Wang Bofei, Pu Shiying, Zhang Xianglin, Zhu Genfeng, Shi Wanliang, Zhang Lu, Wang Honghai, Wang Shengyue, Zhao Guoping, Zhang Ying

Abstract excerpt

Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M. tuberculosis strain H37Ra was derived from virulent strain H37 in 1935 but the basis of virulence attenuation has remained obscure despite numerous studies. We determined the complete genomic sequence of H37Ra ATCC25177 and compared that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18584054
DOI: 10.1371/journal.pone.0002375
PMCID: PMC2440308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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