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Article

The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value.

Journal of clinical laboratory analysis - 1 Nov 2021

Xing Yuhua, Sun Ting, Li Guangxue, Xu Guoan, Cheng Jia, Gao Shugui

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is considered to be one of the best candidate genes for depression. However, whether sertraline treatment affects the methylation level of this gene remains unknown. METHODS: Fifty-three patients with depression and 51 healthy controls were included in the study. The methylation level of BDNF exon I was determined in blood samples from these subjects. The...

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PMID: 34528295
DOI: 10.1002/jcla.23993
PMCID: PMC8605126

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