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Angiogenic Secretion Profile of Valvular Interstitial Cells Varies With Cellular Sex and Phenotype

30 Aug 2021

Abstract excerpt

Angiogenesis is a hallmark of fibrocalcific aortic valve disease (CAVD). An imbalance of pro- and anti-angiogenic factors is thought to play a role in driving this disease process, and valvular interstitial cells (VICs) may act as a significant source of these factors. CAVD is also known to exhibit sexual dimorphism in its presentation, and previous work suggested that VICs may exhibit cellular-scale sex...

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PMID: 34527715
DOI: 10.3389/fcvm.2021.736303

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