Human Aortic Valve Interstitial Cells Display Proangiogenic Properties During Calcific Aortic Valve Disease.

doi:10.1161/ATVBAHA.120.314287

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Article

Human Aortic Valve Interstitial Cells Display Proangiogenic Properties During Calcific Aortic Valve Disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2021

Gendron Nicolas, Rosa Mickael, Blandinieres Adeline, Sottejeau Yoann, Rossi Elisa, Van Belle Eric, Idelcadi Salim, Lecourt Séverine, Vincentelli André, Cras Audrey, Jashari Ramadan, Chocron Richard, Baudouin Yaël, Pamart Thibault, Bièche Ivan, Nevo Nathalie, Cholley Bernard, Rancic Jeanne, Staels Bart, Gaussem Pascale, Dupont Annabelle, Carpentier Alain, Susen Sophie, Smadja David M

Abstract excerpt

OBJECTIVE: The study's aim was to analyze the capacity of human valve interstitial cells (VICs) to participate in aortic valve angiogenesis. Approach and Results: VICs were isolated from human aortic valves obtained after surgery for calcific aortic valve disease and from normal aortic valves unsuitable for grafting (control VICs). We examined VIC in vitro and in vivo potential to differentiate in endothelial and...

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Identifiers

PMID: 33147990
DOI: 10.1161/ATVBAHA.120.314287

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