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Article

Fungal immunomodulatory proteins skew macrophages towards a pro-inflammatory and tumour inhibitory phenotype.

Cancer immunology, immunotherapy : CII - 31 Mar 2026

Liu Yusi, Krzysica Paulina A, Li Zhen, Wichers Harry J, Bastiaan-Net Shanna, Hoppenbrouwers Tamara

Abstract excerpt

BACKGROUND: Tumour-associated macrophages (TAMs) are associated with poor clinical outcome in cancer patients, making them key targets in immunotherapy. TAMs mainly consist of anti-inflammatory M2 macrophages promoting tumour growth, metastasis and immunosuppression. Fungal immunomodulatory protein from Nectria haematococca (FIP-nha) is a potential anti-tumour agent, notably inhibiting tumour cells and exerting...

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Identifiers

PMID: 41915238
DOI: 10.1007/s00262-026-04376-1
PMCID: PMC13038778

Genes

CD163
CD68
CD80

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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