Article
A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin.
Scientific reports - 13 Sept 2021
Chennampally Phaneendra, Sayed-Zahid Ambreen, Soundararajan Prabakaran, Sharp Jocelyn, Cox Gregory A, Collins Scott D, Smith Rosemary L
Abstract excerpt
TAR DNA-binding protein-43 (TDP-43) is known to accumulate in ubiquitinated inclusions of amyotrophic lateral sclerosis affected motor neurons, resulting in motor neuron degeneration, loss of motor functions, and eventually death. Rapamycin, an mTOR inhibitor and a commonly used immunosuppressive drug, has been shown to increase the survivability of Amyotrophic Lateral Sclerosis (ALS) affected motor neurons. Here...
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