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Article

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

Nature chemical biology - 1 Aug 2014

Barmada Sami J, Serio Andrea, Arjun Arpana, Bilican Bilada, Daub Aaron, Ando D Michael, Tsvetkov Andrey, Pleiss Michael, Li Xingli, Peisach Daniel, Shaw Christopher, Chandran Siddharthan, Finkbeiner Steven

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have distinct clinical features but a common pathology--cytoplasmic inclusions rich in transactive response element DNA-binding protein of 43 kDa (TDP43). Rare TDP43 mutations cause ALS or FTD, but abnormal TDP43 levels and localization may cause disease even if TDP43 lacks a mutation. Here we show that individual neurons vary in their ability...

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Identifiers

PMID: 24974230
DOI: 10.1038/nchembio.1563
PMCID: PMC4106236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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