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Article

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device.

Neuroscience research - 1 Jan 2022

Otomo Asako, Ono Suzuka, Sato Kai, Mitsui Shun, Shimakura Kento, Kimura Hiroshi, Hadano Shinji

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective loss of motor neurons. We have previously shown that autophagosome-like vesicular structures are progressively accumulated in the spinal axons of an ALS mouse model, overexpressing human Cu/Zn superoxide dismutase (SOD1) mutant, prior to the onset of motor symptoms. This suggests that axonal transport perturbation can be...

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Identifiers

PMID: 34352295
DOI: 10.1016/j.neures.2021.07.005

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