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Article

Molecular and Clinical Characteristics of Patients with Non-Small Cell Lung Cancer Harboring KRAS G12V Mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2026

John Felix, Ruge Lea, Verheyen Malte, Scharpenseel Heather, Michels Sebastian Yves Friedrich, Riedel Richard, Fischer Rieke, Jakob Carolin, Siemanowski-Hrach Janna, Fassunke Jana, Heydt Carina, Ihle Michaela Angelika, Lyu Su Ir, Rasokat Anna, Schulte Wolfgang, Franke Karl-Josef, Graeven Ullrich, Kappes Jutta, Kron Anna, Siebolts Udo, Merkelbach-Bruse Sabine, Quaas Alexander, Büttner Reinhard, Wolf Jürgen, Scheffler Matthias

Abstract excerpt

PURPOSE: KRAS G12V is among the most frequent KRAS mutations in non-small cell lung cancer (NSCLC), yet its clinical and molecular features remain poorly understood. EXPERIMENTAL DESIGN: In this retrospective study, we analyzed 636 patients with KRAS G12V-mutated NSCLC diagnosed between 2018 and 2023. Clinical, pathologic, and molecular characteristics, including co-mutations, smoking history, programmed cell...

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Identifiers

PMID: 41417462
DOI: 10.1158/1078-0432.CCR-25-2581

Genes

KRAS
KEAP1
TP53
NTRK1
STK11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Molecular and Clinical Characteristics of Patients with Non-Small Cell Lung Cancer Harboring KRAS G12V Mutations.PMID 41417462Read ↗

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