Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer.

doi:10.1016/j.annonc.2022.07.005

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Article

Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2022

Ricciuti B, Alessi J V, Elkrief A, Wang X, Cortellini A, Li Y Y, Vaz V R, Gupta H, Pecci F, Barrichello A, Lamberti G, Nguyen T, Lindsay J, Sharma B, Felt K, Rodig S J, Nishino M, Sholl L M, Barbie D A, Negrao M V, Zhang J, Cherniack A D, Heymach J V, Meyerson M, Ambrogio C, Jänne P A, Arbour K C, Pinato D J, Skoulidis F, Schoenfeld A J, Awad M M, Luo J

Abstract excerpt

BACKGROUND: Allele-specific KRAS inhibitors are an emerging class of cancer therapies. KRAS-mutant (KRASMUT) non-small-cell lung cancers (NSCLCs) exhibit heterogeneous outcomes, driven by differences in underlying biology shaped by co-mutations. In contrast to KRASG12C NSCLC, KRASG12D NSCLC is associated with low/never-smoking status and is largely uncharacterized. PATIENTS AND METHODS: Clinicopathologic and...

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PMID: 35872166
DOI: 10.1016/j.annonc.2022.07.005
PMCID: PMC11006449

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