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Article

Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1.

Blood advances - 8 Feb 2022

Oñate Guadalupe, Bataller Alex, Garrido Ana, Hoyos Montserrat, Arnan Montserrat, Vives Susana, Coll Rosa, Tormo Mar, Sampol Antònia, Escoda Lourdes, Salamero Olga, Garcia Antoni, Bargay Joan, Aljarilla Alba, Nomdedeu Josep F, Esteve Jordi, Sierra Jorge, Pratcorona Marta

Abstract excerpt

The negative prognostic impact of internal tandem duplication of FLT3 (FLT3-ITD) in patients with acute myeloid leukemia with mutated NPM1 (AML-NPM1) is restricted to those with a higher FLT3-ITD allelic ratio (FLT3high; ≥0.5) and considered negligible in those with a wild-type (FLT3WT)/low ITD ratio (FLT3low). Because the comutation of DNMT3A (DNMT3Amut) has been suggested to negatively influence prognosis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34516636
DOI: 10.1182/bloodadvances.2020004136
PMCID: PMC8945292

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