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Article

The FLT3ITD mRNA level has a high prognostic impact in NPM1 mutated, but not in NPM1 unmutated, AML with a normal karyotype.

Blood - 10 May 2012

Schneider Friederike, Hoster Eva, Unterhalt Michael, Schneider Stephanie, Dufour Annika, Benthaus Tobias, Mellert Gudrun, Zellmeier Evelyn, Kakadia Purvi M, Bohlander Stefan K, Feuring-Buske Michaela, Buske Christian, Braess Jan, Heinecke Achim, Sauerland Maria C, Berdel Wolfgang E, Büchner Thomas, Wörmann Bernhard J, Hiddemann Wolfgang, Spiekermann Karsten

Abstract excerpt

The impact of a FLT3-internal tandem duplication (FLT3ITD) on prognosis of patients with acute myeloid leukemia (AML) is dependent on the ratio of mutated to wild-type allele. In 648 normal karyotype (NK) AML patients, we found a significant independent effect of the quantitative FLT3ITD mRNA lev...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22374696
DOI: 10.1182/blood-2010-12-327072

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22374696-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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