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Article

Transcriptional features of biological age maintained in human cultured cardiac interstitial cells.

Genomics - 1 Nov 2021

Echeagaray Oscar, Kim Taeyong, Casillas Alex, Monsanto Megan, Sussman Mark

Abstract excerpt

Ex vivo expansion of cells is necessary in regenerative medicine to generate large populations for therapeutic use. Adaptation to culture conditions prompt an increase in transcriptome diversity and decreased population heterogeneity in cKit+ cardiac interstitial cells (cCICs). The "transcriptional memory" influenced by cellular origin remained unexplored and is likely to differ between neonatal versus senescent...

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PMID: 34509618
DOI: 10.1016/j.ygeno.2021.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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