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In situ transcriptome characteristics are lost following culture adaptation of adult cardiac stem cells

7 Aug 2018

Abstract excerpt

Regenerative therapeutic approaches for myocardial diseases often involve delivery of stem cells expanded ex vivo. Prior studies indicate that cell culture conditions affect functional and phenotypic characteristics, but relationship(s) of cultured cells derived from freshly isolated populations and the heterogeneity of the cultured population remain poorly defined. Functional and phenotypic characteristics of ex...

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PMID: 30104715
DOI: 10.1038/s41598-018-30551-1

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