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Article

A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis.

PLoS pathogens - 1 Sept 2021

Liu Junyan, Willems Hubertine M E, Sansevere Emily A, Allert Stefanie, Barker Katherine S, Lowes David J, Dixson Andrew C, Xu Zhenbo, Miao Jian, DeJarnette Christian, Tournu Helene, Palmer Glen E, Richardson Jonathan P, Barrera Francisco N, Hube Bernhard, Naglik Julian R, Peters Brian M

Abstract excerpt

Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, plays a crucial role in driving immunopathology at the vaginal mucosa. This study aimed to determine if expression and/or processing of Ece1p differs across C. albicans...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34506615
DOI: 10.1371/journal.ppat.1009884
PMCID: PMC8432879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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