Article
Phenotypic and genotypic analysis of Candida albicans vaginal isolates reveals that ECE1 expression underpins pathogenicity.
Infection and immunity - 14 Jul 2026
Davari Amirhossein, Liu Junyan, Fortwendel Jabez P, Luna-Tapia Arturo, Lowes David J, Miao Jian, Willems Hubertine M E, DeJarnette Christian A, Peters Tracy L, Ahmadi Nasim, Naik Surabhi, Swidergall Marc, Rogers P David, Sobel Jack D, Palmer Glen E, Peters Brian M
Abstract excerpt
Candida albicans is the leading cause of vulvovaginal candidiasis (VVC), yet the extent to which strain-level variation influences pathogenic mechanisms remains unclear. Candidalysin, a peptide toxin encoded by ECE1, is a key driver of epithelial damage and immunopathology, but its role has been largely defined in a limited number of laboratory strains. Here, we analyzed a panel of 27 vaginal clinical isolates...
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