Article
Dynamics-Evolution Correspondence in Protein Structures.
Physical review letters - 27 Aug 2021
Tang Qian-Yuan, Kaneko Kunihiko
Abstract excerpt
The genotype-phenotype mapping of proteins is a fundamental question in structural biology. In this Letter, with the analysis of a large dataset of proteins from hundreds of protein families, we quantitatively demonstrate the correlations between the noise-induced protein dynamics and mutation-induced variations of native structures, indicating the dynamics-evolution correspondence of proteins. Based on the...
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