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Article

A new method for revealing correlated mutations under the structural and functional constraints in proteins.

Bioinformatics (Oxford, England) - 1 Oct 2009

Lee Byung-Chul, Kim Dongsup

Abstract excerpt

MOTIVATION: Diverse studies have shown that correlated mutation (CM) is an important molecular evolutionary process alongside conservation. However, attempts to find the residue pairs that co-evolve under the structural and/or functional constraints are complicated by the fact that a large portion of covariance signals found in multiple sequence alignments arise from correlations due to common ancestry and...

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PMID: 19628501
DOI: 10.1093/bioinformatics/btp455

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