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Article

Activin A Sustains the Metastatic Phenotype of Tumor-Associated Macrophages and Is a Prognostic Marker in Human Cutaneous Melanoma.

The Journal of investigative dermatology - 1 Mar 2022

Gutiérrez-Seijo Alba, García-Martínez Elena, Barrio-Alonso Celia, Parra-Blanco Verónica, Avilés-Izquierdo José Antonio, Sánchez-Mateos Paloma, Samaniego Rafael

Abstract excerpt

Tumor cells attract and dynamically interact with monocytes/macrophages to subvert their differentiation into tumor-associated macrophages (TAMs), which mainly promote immune suppression and neoplastic progression, but the pathways and microenvironmental cues governing their protumoral deviation are not completely understood. To identify the molecular pathways responsible for TAM differentiation, we screened the...

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Source

Identifiers

PMID: 34499901
DOI: 10.1016/j.jid.2021.07.179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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