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Distinct genetic landscape and a low response to doxorubicin in a luminal-A breast cancer cell line of Pakistani origin.

Molecular biology reports - 1 Oct 2021

Shakeel Muhammad, Khan Salman Ahmed, Mughal Anum Jabeen, Irfan Muhammad, Hoessli Daniel C, Choudhary M Iqbal, Aurongzeb Muhammad, Khan Ishtiaq Ahmad

Abstract excerpt

BACKGROUND: Breast cancers exhibit genetic heterogeneity which causes differential responses to various chemotherapy agents. Given the unique demographic and genomic background in South Asia, genetic architecture in breast cancers is not fully explored. METHODS AND RESULTS: In this study, we determined the genetic landscape of our previously established luminal-A subtype breast cancer cell line (BC-PAK1), and...

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PMID: 34495459
DOI: 10.1007/s11033-021-06681-7

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